Ropivacaine for local infiltration anesthesia in postoperative analgesia
Local anesthetics can block nociceptive reach the central nervous system, giving local anesthetic before surgery can reduce the surgery and postoperative pain intensity and shorten the duration of pain, reduce patient analgesic requirement. Using long-acting local anesthetic infiltration anesthesia, postoperative analgesia can be used as a supplementary means. Ropivacaine (ropivacaine, RP) is a new amide local anesthetic, similar to its anesthetic effect with bupivacaine, and bupivacaine toxicity significantly weaker than that currently in clinical use of increasingly widely . This paper has done this review. 1. Ropivacaine pharmacological characteristics of ropivacaine bupivacaine piperidine ring card because of the third nitrogen atoms are replaced by the product of n-propyl, for asymmetric single-enantiomer (single enantiomer), the S-image body. It is a pure L-isomer compared with D-isomer of low toxicity, and long time. Its pKa of 8.1, the distribution coefficient of 2.9. The fat-soluble ropivacaine weakened the effectiveness of the small absolute reach the time of delayed gross motor nerves, but for A
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