About three kinds of quinolones to treat respiratory infections cost - Comparison of net write papers _

Network to write papers: [Abstract] Objective To observe the three kinds of quinolones to treat respiratory infections effects of the economic effects of three drugs. Methods hospital 90 cases of respiratory tract infections were randomly divided into 3 groups, A group (n = 30 given intravenous ciprofloxacin therapy, B group (n = 30 given intravenous moxifloxacin treatment, C group (n = 30 given intravenous infusion of levofloxacin treatment, three kinds of quinolones for the cost of - effectiveness analysis results total effective rate in group A and group B, C group, the differences were not significant (P> 0.05, B group the total effective rate was significantly higher than group C, the difference was significant (P <0.05 , A group, B group, C group, the incidence of adverse reactions was no significant difference (P> 0.05,3 drug treatment for every unit needs a treatment cost were 32.31 yuan, 54.19 yuan, 20.02 yuan, C group lowest cost Conclusion levofloxacin in the treatment of respiratory tract infections with the exact efficacy of safety, cost advantages, can be of clinical use.

[Keywords:] pharmacoeconomic cost - effectiveness analysis of drug therapy in the treatment of respiratory tract infections quinolones
Pharmacoeconomics is a combination of pharmacological and interdisciplinary economics, the discipline from an economic point of view, drug development and use of research to make limited resources to maximize the effectiveness of drugs, "cost - effectiveness analysis" is the most common methods of analysis, which cost in monetary units, the effect with biological or clinical unit, cost - effectiveness analysis and cost effectiveness ratio to represent each get a results, the net cost to pay, in a series of similar compare the effect of drug treatment programs, if the final results are similar or the same, the choice of cost - effectiveness ratio is the smallest reasonable treatment options [1]. levofloxacin, ciprofloxacin and moxifloxacin for the treatment of common respiratory tract infections quinolones, these three drugs for this cost - Comparison to explore more safe and economical treatment options, are reported below.

1 Materials and Methods
1.1 General information on use of hospital medical records room to retrieve a computer in February 2008 - June 2010 the clinic of respiratory tract infections, according to the prescription drugs taken out of the Application records of 90 patients with quinolone antibiotics, excluding pregnant women, lactating women, blood disease, epilepsy, urinary tract obstruction, fungal and trichomonas reproductive tract infections, history of quinolone allergy, medication used within 1 week before other classes of antibiotics, with respiratory infection unrelated to other diseases (such as diarrhea, infection, trauma .) selected patients with a total of 90 cases, including 48 male and 42 female, aged 19-87 years old, were randomly divided into 3 groups of 30 patients, comparing three groups of patients with the clinical data, the x2 test, no significant difference sex (P> 0.05, comparable.

1.2 Treatment group A (n = 30 given ciprofloxacin intravenous infusion of 800mg / day (100ml: 0.2g, 0.296 元 / mg, the German company Bayer, B group (n = 30 given intravenous moxifloxacin hydrochloride infusion of 400mg / day (0.4g: 250ml, 0.79 元 / mg, the German company Bayer), C group (n = 30 given intravenous infusion of levofloxacin 400mg / day (0.5g: 100ml, 0.248 元 / mg, the first Japanese a Pharmaceutical Group Beijing Co., Ltd. .3 treatment for 2 weeks.

1.3 observations before and after treatment for bacteriological examination, each patient before treatment, the treatment section 7d, treatment of the first 14d, checks the blood, urine, liver and kidney function, adverse reactions were observed and recorded.

1.4 Effect criteria used here, refers to the specific effect of drug treatment program clinical results, the specific purpose of clinical treatment as a measure, this study clinical efficiency (E% for the results of clinical treatment based on the Ministry of Health the "antibacterial drug clinical research guidelines>> classified as" cured, effective, progressive, invalid "a total of four levels, the total of cases cured and markedly effective; the relationship between adverse reactions and drug classified as" definitely related, probably related, may be relevant, may not be, certainly nothing to do "a total of five levels, the total for the first three levels of incidence of adverse reactions.

1.5 Cost - effectiveness analysis of drug economics, the total direct medical cost = cost + cost + indirect cost of adverse events + others in this group of patients selected were all out-patient department, the same examination aids are not included in the cost analysis, calculated only direct medical costs in the cost of the drug costs, cost - effectiveness ratio (C / E) = cost / efficiency.

1.6 SPSS12.0 software using statistical methods to analyze measurement data to x-+-s that the x2 test, with P <0.05 was considered statistically significant.

2 Results
2.1 treatment and incidence of adverse reactions in group A and B total effective group, C group, the difference was not significant (P> 0.05, B group the total effective rate was significantly higher than group A, the difference was significant (P <0.05), A group, B group, C group, the incidence of adverse reactions was no significant difference (P> 0.05, Table 1. Links to free download http://www.hi138.com Table 1 Group 3 patient outcomes and the incidence of adverse reactions

2.2 Cost - effectiveness analysis of three drugs to get a treatment for each treatment unit costs were required to 32.3 yuan, 54.19 yuan, 20.02 yuan, C group of the lowest cost.


3 Discussion
Clinical treatment of drug treatment of diseases, stressed economy, it means the effect of the investment unit of the medical treatment costs as low as possible, in short, with minimal expenditures on drugs for the treatment of the biggest benefits of drugs as a special commodity, with the general characteristics of goods, the demand for drugs still depends on the value and price, cost - effectiveness analysis of the prime consideration is cost effective to seek effective, a more reasonable cost of drugs, will be "reasonable" and "economic" integration [2].

Application of quinolones are many ways to treat respiratory infections, ciprofloxacin, moxifloxacin, levofloxacin, a new fluoroquinolone antibiotics, commonly used in the treatment of respiratory tract infections. Quinolones main mechanism of action is to inhibit bacterial DNA gyrase activity, thereby impeding bacterial DNA replication, to achieve antibacterial activity, clinical terms Gram-negative bacteria, Grand-positive bacteria sensitive strains caused moderate to severe respiratory system, digestive system, urinary system, skin and soft tissue infections [3]. levofloxacin This product is the L-body ofloxacin, ofloxacin its antibacterial activity is about 2 times the results of this survey showed that levofloxacin in the treatment of respiratory tract infections with moxifloxacin and efficiency have Ciprofloxacin efficiency was no significant difference in the incidence of adverse drug reactions was no significant difference, and levofloxacin cost - effectiveness analysis is better than the other two groups, with clinical value.

References
[1] Xu correct. Pharmacoeconomics and analysis [J]. Chinese medicine and clinical, 2000,19 (2:139-142.

[2] Wang Jianping, Jin Taiyuan, Jiang Lili. Ticarcillin / clavulanate potassium, amoxicillin / clavulanate in the treatment of lower respiratory tract infections in different treatment programs cost - effectiveness analysis [J]. Medicine Herald, 2004, 23 (1) :53-54.

[3] Chen Xiaoling 3 Quinolones treatment of upper respiratory tract infections cost - effectiveness analysis [J]. Chinese Pharmacy, 2008,19 (8:563-564. Links to free download http://www.hi138. com