复发或转移性乳腺癌化疗:首选的单药NCCN2015v3

CHEMOTHERAPY REGIMENS FOR RECURRENT OR METASTATIC BREAST CANCERPreferred single agents:Anthracyclines●Doxorubicin●Pegylated liposomal doxoru

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CHEMOTHERAPY REGIMENS FOR RECURRENT OR METASTATIC BREAST CANCER

Preferred single agents:

Anthracyclines

●Doxorubicin

●Pegylated liposomal doxorubicin

Taxanes

●Paclitaxel Anti-metabolites

●Capecitabine

●Gemcitabine

Other microtubule inhibitors

●Vinorelbine

●Eribulin

Other single agents:

●Cyclophosphamide

●Carboplatin

●Docetaxel

●Albumin-bound paclitaxel

●Cisplatin

●Epirubicin

●Ixabepilone

There is no compelling evidence that combination regimens are superior to sequential single agents.

Randomized clinical trials in metastatic breast cancer document that the addition of bevacizumab to some first- or second-line chemotherapy agents modestly improves time to progression and response rates but does not improve overall survival. The time-to- progression impact may vary among cytotoxic agents and appears greatest with bevacizumab in combination with weekly paclitaxel.

复发或转移性乳腺癌化疗方案

首选的单药:

蒽环类抗生素

●阿霉素

●聚乙二醇脂质体阿霉素

紫杉烷类

●紫杉醇

抗代谢药

●卡培他滨

●吉西他滨

其它微管抑制剂

●长春瑞滨

●艾日布林

其它的单药:

●环磷酰胺

●卡铂

●多西他赛

●白蛋白结合型紫杉醇

●顺铂

●表柔比星

●伊沙匹隆

联合方案优于单药序贯没有令人信服的证据。

转移性乳腺癌随机临床试验证明贝伐单抗加入到某些一线或二线化疗药物适度改善至进展时间和有效率但没有改善总生存。

在细胞毒药物之间至进展时间影响可能不同,贝伐单抗联合每周1次紫杉醇影响似乎最大。

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