复发或转移性乳腺癌化疗方案给药计划——联合化疗

DOSING SCHEDULES FOR CHEMOTHERAPY REGIMENS FOR RECURRENT OR METASTATIC BREAST CANCERChemotherapy combinations:CAF chemotherapy●Cyclophospham

正文

DOSING SCHEDULES FOR CHEMOTHERAPY REGIMENS FOR RECURRENT OR METASTATIC BREAST CANCER

Chemotherapy combinations:

CAF chemotherapy

●Cyclophosphamide 100 mg/m2 PO days 1-14

●Doxorubicin 30 mg/m2 IV days 1 & 8

●5-fluorouracil 500 mg/m2 IV days 1 & 8

Cycled every 28 days.

FAC chemotherapy

●5-fluorouracil 500 mg/m2 IV days 1 & 8 or days 1 & 4

●Doxorubicin 50 mg/m2 IV day 1 (or by 72-h continuous infusion)

●Cyclophosphamide 500 mg/m2 IV day 1

Cycled every 21 days.

FEC chemotherapy

●Cyclophosphamide 400 mg/m2 IV days 1 & 8

●Epirubicin 50 mg/m2 IV days 1 & 8

●5-fluorouracil 500 mg/m2 IV days 1 & 8

Cycled every 28 days.

AC chemotherapy

●Doxorubicin 60 mg/m2 IV day 1

●Cyclophosphamide 600 mg/m2 IV day 1

Cycled every 21 days.

EC chemotherapy

●Epirubicin 75 mg/m2 IV day 1

●Cyclophosphamide 600 mg/m2 IV day 1

Cycled every 21 days.

CMF chemotherapy

●Cyclophosphamide 100 mg/m2 PO days 1-14

●Methotrexate 40 mg/m2 IV days 1 & 8

●5-fluorouracil 600 mg/m2 IV days 1 & 8

Cycled every 28 days.

Docetaxel/capecitabine chemotherapy

●Docetaxel 75 mg/m2 IV day 1

●Capecitabine 950 mg/m2 PO twice daily days 1-14

Cycled every 21 days.

GT chemotherapy

●Paclitaxel 175 mg/m2 IV day 1

●Gemcitabine 1250 mg/m2 IV days 1 & 8 (following paclitaxel on day 1)

Cycled every 21 days.

Gemcitabine/carboplatin

●Gemcitabine 1000 mg/m2 on days 1 & 8

●Carboplatin AUC 2 IV on days 1 & 8

Cycled every 21 days.

Paclitaxel plus bevacizumab

●Paclitaxel 90 mg/m2 by 1 h IV days 1, 8, & 15

●Bevacizumab 10 mg/kg IV days 1 & 15

Cycled every 28 days.

The selection, dosing, and administration of anti-cancer agents and the management of associated toxicities are complex. Modifications of drug dose and schedule and initiation of supportive care interventions are often necessary because of expected toxicities and individual patient variability, prior treatment, and comorbidity. The optimal delivery of anti-cancer agents therefore requires a health care delivery team experienced in the use of anti-cancer agents and the management of associated toxicities in patients with cancer.

复发或转移性乳腺癌化疗方案给药计划

联合化疗:

CAF化疗

●环磷酰胺100mg/㎡口服d1-14

●阿霉素30mg/㎡ iv d1&8

●5-氟尿嘧啶500mg/㎡iv d1&8

每28天为1周期。

FAC化疗

●5-氟尿嘧啶500mg/㎡iv d1&8或d1&4

●阿霉素50mg/㎡ iv d1(或CIV 72h)

●环磷酰胺500mg/㎡iv d1

每21天重复。

FEC化疗

●环磷酰胺400mg/㎡ iv d1&8

●表柔比星50mg/㎡iv d1&8

●5-氟尿嘧啶500mg/㎡iv d1&8

每28天为1周期。

AC化疗

●阿霉素60mg/㎡IV d1

●环磷酰胺600mg/㎡iv d1

每21天重复。

EC化疗

●表阿霉素75mg/㎡ IV d1

●环磷酰胺600mg/㎡iv d1

每21天重复。

CMF化疗

●环磷酰胺100mg/㎡口服d1-14

●甲氨蝶呤40mg/㎡iv d1&8

●5-氟尿嘧啶600mg/㎡iv d1&8

每28天为1周期。

多西他赛/卡培他滨化疗

●多西他赛75mg/㎡ iv d1

●卡培他滨950mg/㎡PO bid d1-14

每21天重复。

GT化疗

●紫杉醇175mg/㎡ iv d1

●吉西他滨1250mg/㎡ iv d1&8(在第1天紫杉醇后)

每21天重复。

●吉西他滨/卡铂

●吉西他滨1000mg/㎡ d1&8

●卡铂AUC 2 IV d1&8

每21天重复。

紫杉醇加贝伐单抗

●紫杉醇90mg/㎡静脉注射1小时第1、8、15天

●贝伐单抗10mg/kg iv d1&15

每28天为1周期。

抗癌药物的选择、剂量和给药以及相关毒性的处理是复杂的。调整药物剂量与方案并启动支持治疗干预常常是必要的因为预期的毒性以及个体患者变异性、既往治疗及并存疾病。因此抗癌药物最佳的实施需要有在癌症患者中抗癌药物使用与相关毒性处理经验的保健医疗团队。

NCCN 2015v3

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