一位美国研究人员认为:HPV-16/18型疫苗不该应用于HPV患者。 马里兰州贝瑟斯塔市国立癌症研究所的Allan Hildesheim和她的同事在哥斯达黎加的一个涵盖2189例HPV DNA阳性患者的调查中发现:没有任何证据表明HPV疫苗能有效清除体内病毒。 这项研究发表在Am



马里兰州贝瑟斯塔市国立癌症研究所的Allan Hildesheim和她的同事在哥斯达黎加的一个涵盖2189例HPV DNA阳性患者的调查中发现:没有任何证据表明HPV疫苗能有效清除体内病毒。

这项研究发表在American Medical Association上,同时其上附有亚特兰大疾病控制与防护中心的Lauri博士的评论,他在评论中讲到:“这种疫苗无任何治疗作用,因此在性行为之前注射疫苗将毫无意义。”

For women with human papillomavirus (HPV) infection, use of the HPV-16/18 vaccine will not accelerate reduction of the virus and should not be used to treat the infection, according to a study in the August 15 issue of JAMA.

HPV vaccines were designed to prevent HPV infection and the development of cervical precancers and cancer. Some research has suggested that HPV vaccines could help clear the virus in women already infected, according to background information in the article.

Allan hildesheim, Ph.D., of the National Cancer Institute, Bethesda, Md., and colleagues conducted a study to address the question of whether women positive for HPV DNA should be encouraged to receive HPV-16/18 vaccination to induce or accelerate clearance of their infections. The trial was conducted in two provinces of Costa Rica and included 2,189 women age 18 to 25 years who were positive for HPV DNA. Participants were randomly assigned to receive three doses of HPV-16/18 vaccine (n = 1,088) or a control hepatitis A vaccine (n = 1,101) over 6 months.

There was no evidence that HPV vaccination significantly altered rates of viral clearance. At the 6-month visit, rates of clearance were 33.4 percent vs. 31.6 percent for HPV-16/18 among participants who received the HPV vaccine and the control vaccine, respectively. At the 12-month visit, rates of clearance among participants in the HPV group and the control group, respectively, were 48.8 percent vs. 49.8 percent for HPV-16/18.

There was no evidence of vaccine effects with further analysis on selected study entry characteristics reflective of disease extent, including HPV-16/18 antibody results, cytologic results, and HPV viral load. Similarly, no evidence of vaccine effects was observed in analyses stratified by other study entry parameters thought to potentially influence clearance rates and efficacy of the vaccine, including time since sexual initiation, oral contraceptive use, cigarette smoking.





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