脾照射的最佳放疗剂量及分割模式

文献要点:1.症状性脾大是血液系统疾病常见的并发症【Symptomatic splenomegaly is a debilitating complication commonly observed in hematologic malignancies and disorder

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文献要点:

1.症状性脾大是血液系统疾病常见的并发症【Symptomatic splenomegaly is a debilitating complication commonly observed in hematologic malignancies and disorders, including chronic lymphocytic leukemia (CLL),myelofibrosis (MF), myeloid metaplasia, lymphoma, prolymphocytic leukemia (PLL),and hairy cell leukemia (HCL).)】

2.直接治疗手段包括手术和脾照射【Approaches directly targeting the spleen include splenectomy or splenic irradiation (SI)】

3.临床最常用的放疗剂量和分割模式为10Gy,1Gy/fx, 2周(The most common dose regimen is 10 Gy in 1 Gy fractions over two weeks.)

4.放疗副反应:因为放疗引起的RTOG 3-4级反应占18.5%,主要反应包括发热,贫血,血小板减少症。

5.更低的放疗剂量和分割模式,5Gy,1Gy/fx, 1周,疗效可能相当【Lower doses (e.g. 5 Gy in 5 fractions) may be equally efficacious. Given the limited hematologic reserve of these patients, clinicians should follow these patients closely and have a low threshold for treating the patients for infection,thrombocytopenia, and anemia)】

6.结论:脾照射是症状性脾大安全有效的治疗方法(Insummary, SI is generally a safe and efficacious method for treating patients with symptomatic splenomegaly.)

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